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M94A2671.TXT
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1994-10-25
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Document 2671
DOCN M94A2671
TI HIV positivity in donated bloods screened negative for HIV antibody,
Thailand, 1993.
DT 9412
AU Auwanit W; Tenprasert S; Bhumisawadi J; Wael C; Department of Medical
Sciences, Ministry of Public Health,; Nonthaburi, Thailand.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):251 (abstract no. PB0433). Unique
Identifier : AIDSLINE ICA10/94369904
AB OBJECTIVES: To determine the number of HIV positivity in donated bloods
routinely screened as negative for HIV antibody at 15 hospital
laboratories in Thailand, during June 1992 to July 1993. METHOD: During
June 1992 to July 1993, a total of 73,292 donated bloods at 15
provincial laboratories in Thailand were routinely screened for HIV
antibody and HIV-P24 antigen. All reactive specimens for HIV antibody
and/or P24 antigen were confirmed by supplemental tests (IFA and/or WB
for HIV antibody and NT for P24 antigen) at the reference laboratory.
Five percents of donated bloods shown non-reactive screening for both
HIV antibody and antigen were randomly collected each day from every
provincial laboratories and were re-tested for HIV antibody and antigen
by ELISA at the reference laboratory in Bangkok to observe a false
negative HIV antibody or antigen results. RESULTS: A median value of the
prevalence of HIV antibody positive blood donors in this study were 2.2%
(range 0.7-5.8%) in the north, 1.45% (range 0.8-2.1%) in the south, 3.7%
in the east and 0.6% in the central of Thailand. The rate of HIV-P24
antigen positive but antibody negative blood donors is 8 per 100,000
donations. Out of 3,564 blood samples which were randomly collected from
the seronegative blood donation units screened at provincial
laboratories, there were 10 blood samples (0.28%) showed HIV antibody
positive results when re-tested by ELISA screening test at reference
laboratory. DISCUSSION AND CONCLUSIONS: The results indicated the high
risk of HIV transmission by blood donation units of the early HIV
infected donor. The pre-blood donation interview has to be maintained to
exclude the donor who has risk behaviors. Furthermore, the cost-benefit
of P24 antigen testing in all blood donation units has to be urgently
considered. Quality assurance among HIV laboratories as well as a
quality control of all HIV reagent kits have to be carried out
continuously to decrease a number of false negative results.
DE *Blood Donors *Developing Countries False Negative Reactions Human
HIV Antibodies/*BLOOD HIV Core Protein p24/BLOOD HIV
Seropositivity/*DIAGNOSIS/IMMUNOLOGY/TRANSMISSION HIV Seroprevalence
Risk Factors Thailand MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).